ABSTRACT Biomedical experimentation on animals is justified, researchers say, because of its enormous benefits to human beings. Sure, animals suffer and die, but that is morally insignificant since the benefits of research incalculably outweigh the evils. Although this utilitarian claim appears straightforward and relatively uncontroversial, it is neither straightforward nor uncontroversial. This defence of animal experimentation is likely to succeed only by rejecting three widely held moral presumptions. We identify these assumptions and explain their relevance to the justification of animal (...) experimentation. We argue that, even if non‐human animals have considerably less moral worth than humans, experimentation is justified only if the benefits are overwhelming. By building on and expanding on arguments offered in earlier papers, we show that researchers cannot substantiate their claims on behalf of animal research. We conclude that there is currently no acceptable utilitarian defence of animal experimentation. Moreover, it is unlikely that there could be one. Since most apologists of animal experimentation rely on utilitarian justifications of their practice, it appears that biomedical experimentation on animals is not morally justified. (shrink)

_Brute Science_ investigates whether biomedical research using animals is, in fact, scientifically justified. Hugh LaFollette and Niall Shanks examine the issues in scientific terms using the models that scientists themselves use. They argue that we need to reassess our use of animals and, indeed, rethink the standard positions in the debate.

Biomedical researchers claim there is significant biomedical information about humans which can be discovered only through experiments on intact animal systems (AMA p. 2). Although epidemiological studies, computer simulations, clinical investigation, and cell and tissue cultures have become important weapons in the biomedical scientists' arsenal, these are primarily "adjuncts to the use of animals in research" (Sigma Xi p. 76). Controlled laboratory experiments are the core of the scientific enterprise. Biomedical researchers claim these should be conducted on intact biological systems, (...) whole animals. By observing the effects of various stimuli in non-human animals, we can form legitimate expectations about the likely effects of these stimuli in humans. Perhaps more importantly, we can understand the biomedical condition's causal mechanisms. (shrink)

Claude Bernard, the father of scientific physiology, believed that if medicine was to become truly scientiifc, it would have to be based on rigorous and controlled animal experiments. Bernard instituted a paradigm which has shaped physiological practice for most of the twentieth century. ln this paper we examine how Bernards commitment to hypothetico-deductivism and determinism led to (a) his rejection of the theory of evolution; (b) his minima/ization of the role of clinical medicine and epidemiological studies; and (c) his conclusion (...) that experiments on nonhuman animals were, "entirely conclusive for the toxicology and hygiene of man". We examine some negative consequences of Bernardianism for twentieth century medicine, and argue that physio/ogy's continued adherence to Bernardianism has caused it to diverge from the other biological sciences which have become increasingly infused with evolutionary theory. (shrink)

Anti-vivisectionists charge that animal experimenters are speciesists people who unjustly discriminate against members of other species. Until recently most defenders of experimentation denied the charge. After the publication of `The Case for the Use of Animals in Biomedical Research' in the New England Journal of Medicine , experimenters had a more aggressive reply: `I am a speciesist. Speciesism is not merely plausible, it is essential for right conduct...'1. Most researchers now embrace Cohen's response as part of their defense of animal (...) experimentation. Cohen asserts that both rights and utilitarian arguments against the use of animals in research fail because they `refuse to recognize the moral differences among species'.2 If we appreciate the profound differences between humans and non-human animals, he says, we would understand why animals do not and could not have rights and why animal pain does not have as much moral weight as human pain. Animal liberationists think speciesism is immoral because they mistakenly equate it with racism and sexism. Cohen claims this equation is `unsound', `atrocious', `utterly specious', and `morally offensive'. Doubtless Cohen is right that the charge of speciesism is founded on an analogy with racism and sexism. He is mistaken, however, in asserting that the comparison is categorically illicit. (shrink)

When theorists have studied humor, they often assumed that laughter was either a necessary or a sufficient condition of humor. It is neither. Although humorous events usually evoke laughter, they do not do so invariably. Humor may evoke smiles or smirks which fall short of laughter. Thus it is not a necessary condition. Nor is it a sufficient condition. People may laugh because they are uncomfortable (nervous laughter), they may laugh at someone (derisive laughter), they may laugh because they are (...) insane or mentally imbalanced (hysterical laughter), or they may laugh because they are physiologically induced to do so (as when someone tickles them relentlessly). Perhaps these other forms of laughter are philosophically interesting, but they are not forms of humor and so are beyond the reach of this essay. (shrink)

In this article we discuss two divergent accounts of non-human animals as analog models of human biomedical phenomena. Using a classical account of analogical reasoning, toxicologists and teratologists claim that if the model and subject modeled are substantially similar, then test results in non-human animals are likely applicable to humans. However, the same toxicologists report that different species often react very differently to the same chemical stimuli. The best way to understand their findings is to abandon the classical view of (...) analogical - i.e., linear - reasoning, and replace it with a version informed by chaos theory. We briefly outline the current understanding of chaos, and trace its implications for toxicology and teratology. (shrink)

Biomedical experimentation on animals is justified, researchers say, because of its enormous benefits to human being. Sure an imals die a nd suffer , but that is m orally insignificant since the benefits of research incalculably outweigh the evils. Although this utilitarian claim appears straightforward and uncontroversial, it is neither straightforw ard n ot uncontroversial. This defense of animal experimentation is like ly to succeed only by rejecting three widely held moral presumptions. W e identify those presumptions and explain their (...) relevance to the justification of animal experimentation. We argue that even if non-human animals have con side rable less moral worth than humans, experimentation is justified only if its benefits are overwhelming. By building on arguments offered in earlier papers, we show that research ers c ann ot substantiate their claims of behalf of animal research. We conclude that there is currently no acceptable utilitarian defense of animal experimentation. Moreover, it is unlikely that they could be one. Since most apologists of animal experimentation rely on utilitarian justifications of their practice, it appears that biomedical experimentation on animals is not morally justified. (shrink)

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically (...) analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and expression, epigenetics, complexity theory, and comparative genomics. (shrink)

BackgroundStructured, systematic methods to formulate consensus recommendations, such as the Delphi process or nominal group technique, among others, provide the opportunity to harness the knowledge of experts to support clinical decision making in areas of uncertainty. They are widely used in biomedical research, in particular where disease characteristics or resource limitations mean that high-quality evidence generation is difficult. However, poor reporting of methods used to reach a consensus – for example, not clearly explaining the definition of consensus, or not stating (...) how consensus group panellists were selected – can potentially undermine confidence in this type of research and hinder reproducibility. Our objective is therefore to systematically develop a reporting guideline to help the biomedical research and clinical practice community describe the methods or techniques used to reach consensus in a complete, transparent, and consistent manner.MethodsThe ACCORD project will take place in five stages and follow the EQUATOR Network guidance for the development of reporting guidelines. In Stage 1, a multidisciplinary Steering Committee has been established to lead and coordinate the guideline development process. In Stage 2, a systematic literature review will identify evidence on the quality of the reporting of consensus methodology, to obtain potential items for a reporting checklist. In Stage 3, Delphi methodology will be used to reach consensus regarding the checklist items, first among the Steering Committee, and then among a broader Delphi panel comprising participants with a range of expertise, including patient representatives. In Stage 4, the reporting guideline will be finalised in a consensus meeting, along with the production of an Explanation and Elaboration document. In Stage 5, we plan to publish the reporting guideline and E&E document in open-access journals, supported by presentations at appropriate events. Dissemination of the reporting guideline, including a website linked to social media channels, is crucial for the document to be implemented in practice.DiscussionThe ACCORD reporting guideline will provide a set of minimum items that should be reported about methods used to achieve consensus, including approaches ranging from simple unstructured opinion gatherings to highly structured processes. (shrink)

_The Practice of Ethics_ is an outstanding guide to the burgeoning field of applied ethics, and offers a coherent narrative that is both theoretically and pragmatically grounded for framing practical issues. Discusses a broad range of contemporary issues such as racism, euthanasia, animal rights, and gun control. Argues that ethics must be put into practice in order to be effective. Draws upon relevant insights from history, psychology, sociology, law and biology, as well as philosophy. An excellent companion to LaFollette's (...) authoritative anthology, _Ethics in Practice: An Anthology, Third Edition_. (shrink)

Unmatched in scholarship and scope, The International Encyclopedia of Ethics is the definitive single-source reference work on Ethics, available both in print and online. Comprises over 700 entries, ranging from 1000 to 10,000 words in length, written by an international cast of subject experts Is arranged across 9 fully cross-referenced volumes including a comprehensive index Provides clear definitions and explanations of all areas of ethics including the topics, movements, arguments, and key figures in Normative Ethics, Metaethics, and Practical Ethics Covers (...) the major philosophical and religious traditions Offers an unprecedented level of authority, accuracy and balance with all entries being blind peer-reviewed. (shrink)

A number of health care professionals assert a right to be exempt from performing some actions currently designated as part of their standard professional responsibilities. Most advocates claim that they should be excused from these duties simply by averring that they are conscientiously opposed to performing them. They believe that they need not explain or justify their decisions to anyone; nor should they suffer any undesirable consequences of such refusal. Those who claim this right err by blurring or conflating three (...) issues about the nature and role of conscience, and its significance in determining what other people should permit them to do (or not do). Many who criticize those asserting an exemption conflate the same questions and blur the same distinctions, if not expressly, by failing to acknowledge that sometimes a morally serious agent should not do what she might otherwise be expected to do. Neither side seems to acknowledge that in some cases both claims are true: a conscientious professional should not do her professional duty AND others need not permit or excuse her refusal. I identify these conflations and specify conditions in which a professional might reasonably refuse to do what she is required to do. Then I identify conditions in which the public should exempt a professional from some of her responsibilities. I argue that professionals should refuse far less often than most advocates do . . . and that they should be even less frequently exempt for that failure. Finally, there are compelling reasons why we could not implement a consistent moral policy giving advocates what they want, likely not even in qualified form. (shrink)

In this review we consider the new science of Darwinian medicine. While it has often been said that evolutionary theory is the glue that holds the disparate branches of biological inquiry together and gives them direction and purpose, the links to biomedical inquiry have only recently been articulated in a coherent manner. Our aim in this review is to make clear first of all, how evolutionary theory is relevant to medicine; and secondly, how the biomedical sciences have enriched our understanding (...) of evolutionary processes. We will conclude our review with some observations of the philosophical significance of this interplay between evolutionary theory and the biomedical sciences. (shrink)

This volume is a philosophical introduction and exploration of the nature and value of personal relationships. It is an ideal text for introductory philosophy, ethics, or applied ethics courses.

The fourth edition of _Ethics in Practice_ offers an impressive collection of 70 new, revised, and classic essays covering 13 key ethical issues. Essays integrate ethical theory and the discussion of practical moral problems into a text that is ideal for introductory and applied ethics courses. A fully updated and revised edition of this authoritative anthology of classic and contemporary essays covering a wide range of ethical and moral issues Integrates ethical theory with discussions of practical moral problems, and includes (...) three essays on theory written specifically for this volume Nearly half of the essays are written or revised exclusively for this anthology, which now also features eleven essays new to this edition, as well as expanded sections discussing theory, reproductive technologies, war and terrorism, and animals Content allows teachers to discuss discrete practical issues, focus on the broader grouping of topics, or focus on common themes which bridge sections Section introductions not only outline the basic issues discussed in the essays, but relate them to theoretical perspectives and practical issues discussed elsewhere in the book. Guides students with supporting introductory essays on reading philosophy, theorizing about ethics, writing a philosophy paper, and a supporting web site at www.hughlafollette.com/eip4/. (shrink)

Building on the strengths of the highly successful first edition, the extensively updated _Blackwell Guide to Ethical Theory_ presents a complete state-of-the-art survey, written by an international team of leading moral philosophers. __ A new edition of this successful and highly regarded _Guide_, now reorganized and updated with the addition of significant new material Includes 21 essays written by an international team of leading philosophers Extensive, substantive essays develop the main arguments of all the leading viewpoints in ethical theory Essays (...) new to this edition cover evolution and ethics, capability ethics, virtues and consequences, and the implausibility of virtue ethics. (shrink)

Here is presented for the first time a comprehensive review and analysis of the several roles played by idealization procedures in the logic, mathematics and models that lie at the heart of modern, twentieth century physics. It is only through idealization of one form or another that the objects and processes of modern physics become tractable. The essays in this volume will be of interest to all those who are concerned with the uses of models in physics, and the relationships (...) between models and the real world. The essays in this volume cover the role of idealization in all the main areas of modern physics, ranging from quantum theory, relativity theory and cosmology to chaos theory. (shrink)

Our actions, individually and collectively, inevitably affect others, ourselves, and our institutions. They shape the people we become and the kind of world we inhabit. Sometimes those consequences are positive, a giant leap for moral humankind. Other times they are morally regressive. This propensity of current actions to shape the future is morally important. But slippery slope arguments are a poor way to capture it. That is not to say we can never develop cogent slippery slope arguments. Nonetheless, given their (...) most common usage, it would be prudent to avoid them in moral and political debate. They are often fallacious and have often been used for ill. They are normally used to defend the moral status quo. Even when they are cogent, we can always find an alternate way to capture their insights. Finally, by accepting that the moral roads on which we travel are slippery, we become better able to successfully navigate them. (shrink)

This chapter contains sections titled: The Basic Options The Developmental Alternative Strong Obligation to Assist Conclusion Acknowledgments.

We think about personal relationships in two distinct ways. The first focuses on relationships between blood relatives: parents and their children, siblings, and perhaps first cousins. The second focuses on intimacy: relationships where each individual is honest to and trusting of the other; each cares for the other and seeks the other’s company. In this article I ask how these two conceptions are, can be, or should be linked. Should we strive to make all relationships with kin intimate? Even if (...) the answer is a qualified “No,” does that mean relationships with kin are not valuable? I offer some tentative answers to these questions. Despite its limitations, I hope this provides a framework from which future exploration of these issues might profitably begin. (shrink)

A newly revised (currently in production) edition of LaFollette's classic anthology, with extensive introductory essays by the editor. Essays focus on fourteen different practical ethical issues, grouped into four subject areas. It includes a dozen newly written or revised essays.

Julian H. Franklin. Animal Rights and Moral Philosophy. xix + 151 pp., bibl., index. New York: Columbia University Press, 2005. $35 .; Lorraine Daston; Gregg Mitman . Thinking with Animals: New Perspectives on Anthropomorphism. vi + 230 pp., table, notes, index. New York: Columbia University Press, 2005. $49.50 (cloth.

To varying degrees, many of us think we are “self-made.” Some explicitly state—while others imply—that our accomplishments resulted (almost) entirely from our intelligence, ingenuity, and hard work There is qualified truth in this supposition, even although it is commonly overstated. Others think they are pawns in the chess game of life. However, although some have less control than those more privileged, few are devoid of control. This tandem of judgments is akin to our propensity to make asymmetrical judgments about our (...) actions (and those we like) relative to judgments of those we dislike. We often blame our failures on something other than our ill-advised choices, limited abilities, or lack of persistence. If we receive a poor grade, do not land a desired job or coveted promotion, or are spurned by a potential lover, we often blame another, bad luck, or unfortunate circumstances. We scrounge for ways to excuse or mitigate our responsibility when things turn out badly, while taking credit when actions turn out well. We do not do same for negative traits or actions of those we dislike. The phenomenon I discuss in this paper, however, is more pervasive than blame-deflection or inappropriate pride. Even some who think the notion of the “self-made person” borders on a straw person, also think that we have considerable direct control of our lives. We do not. Although we are not leaves tossed by winds of circumstance, we are shaped by complex causal chains largely beyond our control. After seeing this broadly and in detail, we understand the limits on control and why it is not direct By understanding that and how we are shaped by cultures, governments, businesses, and others, we can isolate levers that help us maximize control we do have. (shrink)

We think about personal relationships in two distinct ways. The first focuses on relationships between blood relatives: parents and their children, siblings, and perhaps first cousins. The second focuses on intimacy: relationships where each individual is honest to and trusting of the other; each cares for the other and seeks the other’s company. In this article I ask how these two conceptions are, can be, or should be linked. Should we strive to make all relationships with kin intimate? Even if (...) the answer is a qualified “No,” does that mean relationships with kin are not valuable? I offer some tentative answers to these questions. Despite its limitations, I hope this provides a framework from which future exploration of these issues might profitably begin. (shrink)

The definitive encyclopedia of ethics, with more than 800 entries, written by preeminent thinkers from around the world, on topics, thinkers, and issues in normative, practical, theoretical, and religious ethics.

This volume is a philosophical introduction and exploration of the nature and value of personal relationships. It is an ideal text for introductory philosophy, ethics, or applied ethics courses.

The definitive ethics resource. By the time the second edition is published, it will have more than 850 entries (more than 200 revised since the first edition), averaging more than 4,000 words. Authors are known authorities, coming from more than 30 countries from all six inhabited continents. Essays were double-blind reviewed.